Drawing on statistical analysis, novel organic carbon capture agents have been developed for integration into bio-based carbon capture and utilization (BiCCU) systems. The BiCCU approach provides a cost-efficient alternative by eliminating the thermal swings typically associated with CO₂ adsorption and desorption, removing the need for compression, and reducing requirements for CO₂ source purity. Nevertheless, a major challenge persists: microorganisms responsible for CO₂ conversion exhibit significant toxicity toward conventional capture agents, necessitating operation at lower concentrations. This research seeks to develop capture agents with enhanced biocompatibility while maintaining high CO₂ loading capacity. By introducing biocompatibility as an equally critical design parameter, this work establishes a new paradigm in carbon capture agent development compared to traditional approaches.